Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte
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چکیده
Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte 3 Enhancer Factor 2D 4 5 Min Du, Robert L. S. Perry, Nathaniel B. Nowacki, Joseph W. Gordon, Jahan 6 Salma, Jianzhong Zhao, Arif Aziz, Joseph Chan, K. W. Michael Siu, John C. 7 McDermott 8 1 Department of Biology, York University, Toronto M3J 1P3, Ontario, Canada; 2 Centre 9 for Research in Mass Spectrometry, York University, Toronto M3J 1P3, Ontario, 10 Canada; 3 Department of Chemistry, York University, Toronto M3J 1P3, Ontario, 11 Canada. 12 * To whom correspondence should be addressed. Email: [email protected] 13
منابع مشابه
Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D.
Activation of protein kinase A (PKA) by elevation of the intracellular cyclic AMP (cAMP) level inhibits skeletal myogenesis. Previously, an indirect modulation of the myogenic regulatory factors (MRFs) was implicated as the mechanism. Because myocyte enhancer factor 2 (MEF2) proteins are key regulators of myogenesis and obligatory partners for the MRFs, here we assessed whether these proteins c...
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تاریخ انتشار 2008